Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2

Palermo, Richard D, Webb, Helen M, Gunnell, Andrea and West, Michelle J (2008) Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2. Biochemical Society Transactions, 36 (4). pp. 625-8. ISSN 0300-5127

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Abstract

The EBNA 2 (Epstein-Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by the cancer-associated EBV (Epstein-Barr virus) and for the continuous proliferation of infected cells. EBNA 2 activates transcription from the viral Cp (C promoter) during infection to generate the 120 kb transcript that encodes all nuclear antigens required for immortalization by EBV. EBNA 2 contains an acidic activation domain and can interact with a number of general transcription factors and co-activators. It is now becoming clear, however, that the regulation of transcription elongation in addition to initiation by EBNA 2, at least in part through CDK9 (cyclin-dependent kinase 9)-dependent phosphorylation of the RNA polymerase C-terminal domain, is likely to play a crucial role in the mechanism of action of this key viral protein.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Q Science > QR Microbiology > QR0355 Virology
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Depositing User: Michelle West
Date Deposited: 03 May 2012 12:43
Last Modified: 03 May 2012 12:43
URI: http://sro.sussex.ac.uk/id/eprint/38767
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