Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell

George, Uduak Z, Stéphanou, Angélique and Madzvamuse, Anotida (2012) Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell. Journal of Mathematical Biology, 66 (3). pp. 547-593. ISSN 0303-6812

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Abstract

The aim of this article is to study cell deformation and cell movement by considering both the mechanical and biochemical properties of the cortical network of actin filaments and its concentration. Actin is a polymer that can exist either in fil- amentous form (F-actin) or in monometric form (G-actin) (Chen et al. 2000) and the filamentous form is arranged in a paired helix of two protofilaments (Ananthakrish- nan et al. 2006). By assuming that cell deformations are a result of the cortical actin dynamics in the cell cytoskeleton, we consider a continuum mathematical model that couples the mechanics of the network of actin filaments with its bio-chemical dy- namics. Numerical treatment of the model is carried out using the moving grid finite element method (Madzvamuse et al. 2003). Furthermore, by assuming slow deforma- tions of the cell, we use linear stability theory to validate the numerical simulation results close to bifurcation points. Far from bifurcation points, we show that the math- ematical model is able to describe the complex cell deformations typically observed in experimental results. Our numerical results illustrate cell expansion, cell contrac- tion, cell translation and cell relocation as well as cell protrusions. In all these results, the contractile tonicity formed by the association of actin filaments to the myosin II motor proteins is identified as a key bifurcation parameter.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: Q Science > QA Mathematics > QA0299 Analysis. Including analytical methods connected with physical problems
Depositing User: Anotida Madzvamuse
Date Deposited: 16 Apr 2012 08:50
Last Modified: 07 Mar 2017 04:58
URI: http://sro.sussex.ac.uk/id/eprint/38655

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