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Cell signaling: The BRCT domain: signaling with friends?
The tandem BRCT domains of the tumor suppressor protein BRCA1 are thought to contribute to this protein's function in the cellular response to DNA damage. In his Perspective, Caldecott discusses new work ( Yu et al., Manke et al.) showing that the BRCT domains of BRCA1 and of other proteins bind specifically to phosphorylated amino acids in their protein partners.
History
Publication status
- Published
Journal
ScienceISSN
0036-8075Publisher
American Association for the Advancement of ScienceExternal DOI
Issue
5645Volume
302Page range
579-580Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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