Clarifying the mechanics of DNA strand exchange in meiotic recombination

Neale, Matt and Keeney, S (2006) Clarifying the mechanics of DNA strand exchange in meiotic recombination. Nature, 442 (7099). pp. 153-158. ISSN 00280836

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Abstract

During meiosis, accurate separation of maternal and paternal chromosomes requires that they first be connected to one another through homologous recombination. Meiotic recombination has many intriguing but poorly understood features that distinguish it from recombination in mitotically dividing cells, and several of these features depend on the meiosis-specific DNA strand exchange protein Dmc1 (disrupted meiotic cDNA1). Many questions about this protein have arisen since its discovery more than a decade ago, but recent genetic and biochemical breakthroughs promise to shed light on the unique behaviours and functions of this central player in the remarkable chromosome dynamics of meiosis.

Item Type: Article
Additional Information: Researched the literature, wrote much of the text, produced all the figures.
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Matt Neale
Date Deposited: 06 Feb 2012 21:25
Last Modified: 30 Jul 2012 08:46
URI: http://sro.sussex.ac.uk/id/eprint/31162
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