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Clarifying the mechanics of DNA strand exchange in meiotic recombination
During meiosis, accurate separation of maternal and paternal chromosomes requires that they first be connected to one another through homologous recombination. Meiotic recombination has many intriguing but poorly understood features that distinguish it from recombination in mitotically dividing cells, and several of these features depend on the meiosis-specific DNA strand exchange protein Dmc1 (disrupted meiotic cDNA1). Many questions about this protein have arisen since its discovery more than a decade ago, but recent genetic and biochemical breakthroughs promise to shed light on the unique behaviours and functions of this central player in the remarkable chromosome dynamics of meiosis.
History
Publication status
- Published
Journal
NatureISSN
00280836Publisher
Nature Publishing GroupExternal DOI
Issue
7099Volume
442Page range
153-158Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Notes
Researched the literature, wrote much of the text, produced all the figures.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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