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The Y-family DNA polymerase ? (pol ?) functions in mammalian nucleotide-excision repair
DNA polymerase ¿ (pol ¿) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol ¿-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol ¿ in mammalian NER.
History
Publication status
- Published
Journal
Nature Cell BiologyISSN
1465-7392Publisher
Nature Publishing GroupExternal DOI
Issue
6Volume
8Page range
640-642Pages
3.0Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Notes
Work carried out entirely in my lab. Describes unexpected discovery of role for a Y-family polymerase in nucleotide excision repair.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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