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The Y-family DNA polymerase ? (pol ?) functions in mammalian nucleotide-excision repair

journal contribution
posted on 2023-06-08, 09:26 authored by Tomoo Ogi, Alan LehmannAlan Lehmann
DNA polymerase ¿ (pol ¿) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol ¿-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol ¿ in mammalian NER.

History

Publication status

  • Published

Journal

Nature Cell Biology

ISSN

1465-7392

Publisher

Nature Publishing Group

Issue

6

Volume

8

Page range

640-642

Pages

3.0

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

Work carried out entirely in my lab. Describes unexpected discovery of role for a Y-family polymerase in nucleotide excision repair.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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