Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease

Ateh, D, Hussain, I, Mustafa, A, Price, K M, Nickols, C D, Bird, M M, Greensmith, L, Schiavo, G, Hafezparast, M, Fisher, E M C, Baker, C S and Martin, J E (2006) Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease. Journal of Pathology, 208 (S1). 23A-23A. ISSN 0022-3417

Full text not available from this repository.

Abstract

Cytoplasmic dynein and its activating complex dynactin drive the retrograde transport of material necessary for the survival and proper functioning of neurons. Disruption of the dynein-dynactin complex by either over-expression of the dynamitin subunit or by mutations within individual dynein/dynactin subunits can cause motor neuron degeneration.

Item Type: Article
Additional Information: 189th Meeting of the Pathological Society of Great Britain and Ireland. Robinson College, Cambridge. 4-6th January, 2006
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 21:13
Last Modified: 02 Jul 2012 14:18
URI: http://sro.sussex.ac.uk/id/eprint/30309
📧 Request an update