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SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice

journal contribution
posted on 2023-06-08, 09:12 authored by Derek C Rogers, Jo Peters, Joanne E Martin, Simon Ball, Sharon J Nicholson, Abi S Witherden, Majid HafezparastMajid Hafezparast, Judy Latcham, Tracey L Robinson, Charlotte A Quilter, Elizabeth M C Fisher
Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.

History

Publication status

  • Published

Journal

Neuroscience Letters

ISSN

0304-3940

Issue

1-2

Volume

306

Page range

89-92

Pages

4.0

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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