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SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice
journal contribution
posted on 2023-06-08, 09:12 authored by Derek C Rogers, Jo Peters, Joanne E Martin, Simon Ball, Sharon J Nicholson, Abi S Witherden, Majid HafezparastMajid Hafezparast, Judy Latcham, Tracey L Robinson, Charlotte A Quilter, Elizabeth M C FisherMouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.
History
Publication status
- Published
Journal
Neuroscience LettersISSN
0304-3940External DOI
Issue
1-2Volume
306Page range
89-92Pages
4.0Department affiliated with
- Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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