SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice

Rogers, Derek C, Peters, Jo, Martin, Joanne E, Ball, Simon, Nicholson, Sharon J, Witherden, Abi S, Hafezparast, Majid, Latcham, Judy, Robinson, Tracey L, Quilter, Charlotte A and Fisher, Elizabeth M C (2001) SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice. Neuroscience Letters, 306 (1-2). pp. 89-92. ISSN 0304-3940

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Abstract

Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Majid Hafezparast
Date Deposited: 06 Feb 2012 21:11
Last Modified: 26 Mar 2012 14:04
URI: http://sro.sussex.ac.uk/id/eprint/30105
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