XRCC1 and DNA strand break repair

Caldecott, Keith (2003) XRCC1 and DNA strand break repair. DNA Repair, 2 (9). pp. 955-969. ISSN 1568-7864

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Abstract

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision repair, or directly from damage to deoxyribose. Because single-strand breaks are induced by endogenous reactive molecules such as reactive oxygen species, these lesions pose a continuous threat to genetic integrity. XRCC1 protein plays a major role in facilitating the repair of single-strand breaks in mammalian cells, via an ability to interact with multiple enzymatic components of repair reactions. Here, the protein¿protein interactions facilitated by XRCC1, and the repair processes in which these interactions operate, are reviewed. Models for the repair of single-strand breaks during base excision repair and at direct breaks are presented.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Keith Caldecott
Date Deposited: 06 Feb 2012 21:11
Last Modified: 13 Jun 2012 13:54
URI: http://sro.sussex.ac.uk/id/eprint/30038
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