Proximal-distal leg development in Drosophila requires the apterous gene and the lim 1 homogue dlim1

Pueyo, Jose, Galindo, Maximo I, Bishop, Sarah A and Couso, Juan P (2000) Proximal-distal leg development in Drosophila requires the apterous gene and the lim 1 homogue dlim1. Development, 127 (24). pp. 5391-5402. ISSN 0950-1991

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Abstract

Proximal-distal leg development in Drosophila involves a battery of genes expressed and required in specific proximal-distal (PD) domains of the appendage. Here we report the characterisation of a new gene of this type, dlim 1, a member of the Lhx family of genes whose proteins contain two Lim domains and a homeodomain. We show that the Lhx gene apterous (ap) is also required for PD leg development, and we study the functional interactions between ap, dlim1 and other PD genes during leg development. Our results show that a regulatory network formed by ap and dlim1 plus the homeobox genes aristaless and Bar specifies distal leg cell fates in Drosophila.

Item Type: Article
Additional Information: Discusses the role in limb development of a putative combinatorial code of LIM and Hox proteins which specify neural fates in insects and vertebrates
Schools and Departments: School of Life Sciences > Biochemistry
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Depositing User: Jose Pueyo-Marques
Date Deposited: 06 Feb 2012 21:10
Last Modified: 21 Sep 2017 10:33
URI: http://sro.sussex.ac.uk/id/eprint/29923
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