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Proximal-distal leg development in Drosophila requires the apterous gene and the lim 1 homogue dlim1
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posted on 2023-06-08, 09:04 authored by Jose Pueyo-Marques, Maximo I Galindo, Sarah Bishop, Juan Pablo CousoProximal-distal leg development in Drosophila involves a battery of genes expressed and required in specific proximal-distal (PD) domains of the appendage. Here we report the characterisation of a new gene of this type, dlim 1, a member of the Lhx family of genes whose proteins contain two Lim domains and a homeodomain. We show that the Lhx gene apterous (ap) is also required for PD leg development, and we study the functional interactions between ap, dlim1 and other PD genes during leg development. Our results show that a regulatory network formed by ap and dlim1 plus the homeobox genes aristaless and Bar specifies distal leg cell fates in Drosophila.
History
Publication status
- Published
Journal
DevelopmentISSN
0950-1991Publisher
DevelopmentPublisher URL
Issue
24Volume
127Page range
5391-5402ISBN
0950-1991Department affiliated with
- Biochemistry Publications
Notes
Discusses the role in limb development of a putative combinatorial code of LIM and Hox proteins which specify neural fates in insects and vertebratesFull text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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