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A dissection of volatility in yeast
journal contribution
posted on 2023-06-08, 09:04 authored by Nina Stoletzki, John Welch, Joachim Hermisson, Adam Eyre-WalkerAdam Eyre-WalkerIt has been suggested that volatility, the proportion of mutations which change an amino acid, can be used to infer the level of natural selection acting upon a gene. This conjecture is supported by a correlation between volatility and the rate of nonsynonymous substitution (dN), or the ratio of nonsynonymous and synonymous substitution rates, in a variety of organisms. These organisms include yeast, in which the correlations are quite strong. Here we show that these correlations are a by-product of a correlation between synonymous codon bias toward translationally optimal codons and dN. Although this analysis suggests that volatility is not a good measure of the selection, we suggest that it might be possible to infer something about the level of natural selection, from a single genome sequence, using translational codon bias.
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Publication status
- Published
Journal
Journal of Molecular EvolutionISSN
0022-2844External DOI
Issue
10Volume
22Page range
2022-2026Pages
5.0Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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