Synonymous codon bias is not caused by mutation bias in G+C rich genes in humans

Smith, N G and Eyre-Walker, A (2001) Synonymous codon bias is not caused by mutation bias in G+C rich genes in humans. Molecular Biology and Evolution, 18 (6). pp. 982-986. ISSN 0737-4038

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Abstract

It is has been suggested that synonymous codon bias is a consequence of mutation bias in mammals. We tested this hypothesis in humans using single-nucleotide polymorphism data. We found a pattern of polymorphism which was inconsistent with the mutation bias hypothesis in G+C-rich genes. However, the data were consistent with the action of natural selection or biased gene conversion. Similar patterns of polymorphism were also observed in noncoding DNA, suggesting that natural selection or biased gene conversion may affect large tracts of the human genome.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 21:09
Last Modified: 22 Mar 2012 14:29
URI: http://sro.sussex.ac.uk/id/eprint/29859
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