The probability of neurotransmitter release: variability and feedback control at single synapses

Branco, Tiago and Staras, Kevin (2009) The probability of neurotransmitter release: variability and feedback control at single synapses. Nature Reviews Neuroscience, 10. pp. 373-383. ISSN 1471-003X

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Abstract

Information transfer at chemical synapses occurs when vesicles fuse with the plasma membrane and release neurotransmitter. This process is stochastic and its likelihood of occurrence is a crucial factor in the regulation of signal propagation in neuronal networks. The reliability of neurotransmitter release can be highly variable: experimental data from electrophysiological, molecular and imaging studies have demonstrated that synaptic terminals can individually set their neurotransmitter release probability dynamically through local feedback regulation. This local tuning of transmission has important implications for current models of single-neuron computation.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Kevin Staras
Date Deposited: 06 Feb 2012 21:09
Last Modified: 26 Mar 2012 13:47
URI: http://sro.sussex.ac.uk/id/eprint/29848
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