Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II

Ward, Simon E, Eddershaw, Peter, Flynn, Sean T, Gordon, Laurie, Lovell, Peter J, Moore, Susan H, Scott, Claire M, Smith, Paul W, Thewlis, Kevin M and Wyman, Paul A (2009) Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II. Bioorganic and Medicinal Chemistry Letters, 19 (2). pp. 428-432. ISSN 0960-894X

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Abstract

A series of 5-( piperidinylethyloxy) quinoline 5-HT1 receptor ligands have been studied by elaboration of the series of dual 5-HT1-SSRIs reported previously. These new compounds display a different in vitro pharmacological pro. le with potent affinity across the 5-HT1A, 5-HT1B and 5-HT1D receptors and selectivity against the serotonin transporter. Furthermore, they have improved pharmacokinetic profiles and CNS penetration.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Simon Ward
Date Deposited: 06 Feb 2012 21:08
Last Modified: 08 Jun 2012 14:04
URI: http://sro.sussex.ac.uk/id/eprint/29719
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