N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators

Thewlis, Kevin M, Aldegheri, Laura, Harries, Mark H, Mookherjee, Claudette, Oliosi, Beatrice and Ward, Simon E (2010) N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7116-7119. ISSN 0960-894X

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Abstract

A series of novel AMPA receptor positive modulators displaying CNS penetration have been discovered with sub-micromolar activity and good selectivity over the cardiac channel receptor, hERG. We describe here the synthesis of these compounds which are biaryl pyrrolidine and tetrahydrofuran sulfonamides and disclose their activities against the human GluA2 flip isoform homotetrameric receptor.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Simon Ward
Date Deposited: 06 Feb 2012 21:04
Last Modified: 30 Nov 2012 17:09
URI: http://sro.sussex.ac.uk/id/eprint/29383
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