Structural analyses of fibrinogen amyloid fibrils

Serpell, Louise C, Benson, Merrill, Liepnieks, Juris J and Fraser, Paul E (2007) Structural analyses of fibrinogen amyloid fibrils. Amyloid, 14 (3). pp. 199-203. ISSN 1350-6129

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Abstract

Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aa-chain. To investigate the structure of fibrinogen amyloid, fibrils were extracted from the tissues of a patient and studied by X-ray fiber diffraction and electron microscopy. We have carried out a full structural characterization of amyloid fibrils taken from disease tissue. These studies revealed that ex vivo fibrinogen amyloid fibrils have a cross-ß structure similar to other chemical types of amyloid fibrils.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Louise Serpell
Date Deposited: 06 Feb 2012 21:03
Last Modified: 07 Jun 2012 14:52
URI: http://sro.sussex.ac.uk/id/eprint/29283
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