Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovis

Smith, Noel H, Gordon, Stephen V, de la Rua-Domenach, Ricardo, Clifton-Hadley, Richard S and Hewinson, R Glyn (2006) Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovis. Nature Reviews Microbiology, 4 (9). pp. 670-681. ISSN 1740-1526

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Abstract

Mycobacterium bovis is the cause of tuberculosis in cattle and is a member of the Mycobacterium tuberculosis complex. In contrast to many other pathogenic bacterial species, there is little evidence for the transfer and recombination of genes between cells. The clonality of this group of organisms indicates that the population structure is dominated by reductions in diversity, caused either by population bottlenecks or selective sweeps as entire chromosomes become fixed in the population. We describe how these forces have shaped not only the phylogeny of this group but also, at a very local level, the population structure of Mycobacterium bovis in the British Isles. We also discuss the practical implications of applying this knowledge to understanding the spread of infection and the development of improved vaccines and diagnostic tests

Item Type: Article
Additional Information: 70% - lead author Contains original research that identifies the two most likely causes of the bovine TB epidemic in the British Isles. These ideas are now being explored by DEFRA research grants.
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 20:59
Last Modified: 30 Nov 2012 17:09
URI: http://sro.sussex.ac.uk/id/eprint/28985
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