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Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovis
journal contribution
posted on 2023-06-08, 08:25 authored by Noel H Smith, Stephen V Gordon, Ricardo de la Rua-Domenach, Richard S Clifton-Hadley, R Glyn HewinsonMycobacterium bovis is the cause of tuberculosis in cattle and is a member of the Mycobacterium tuberculosis complex. In contrast to many other pathogenic bacterial species, there is little evidence for the transfer and recombination of genes between cells. The clonality of this group of organisms indicates that the population structure is dominated by reductions in diversity, caused either by population bottlenecks or selective sweeps as entire chromosomes become fixed in the population. We describe how these forces have shaped not only the phylogeny of this group but also, at a very local level, the population structure of Mycobacterium bovis in the British Isles. We also discuss the practical implications of applying this knowledge to understanding the spread of infection and the development of improved vaccines and diagnostic tests
History
Publication status
- Published
Journal
Nature Reviews MicrobiologyISSN
1740-1526External DOI
Issue
9Volume
4Page range
670-681Pages
12.0Department affiliated with
- Biology and Environmental Science Publications
Notes
70% - lead author Contains original research that identifies the two most likely causes of the bovine TB epidemic in the British Isles. These ideas are now being explored by DEFRA research grants.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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