The hydroxylation of the sequiterpenoid valerianol by Mucor plumbeus

Arantes, Simone Fontes, Hanson, James R and Hitchcock, Peter B (1999) The hydroxylation of the sequiterpenoid valerianol by Mucor plumbeus. Phytochemistry, 52. 1063 - 1067. ISSN 0031-9422

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Abstract

The sesquiterpenoid valerianol 2 is a constituent of valerian oil (Jommi, Krepinsky, Herout & Sorm, 1969) and it may be prepared by the oxy-mercuration of commercially available valencene 1 (Fontes Arantes, Hanson & Hitchcock, 1999). Valerianol is identical to kusenol which was obtained (Hikino, Suzuki & Takemoto, 1968) from the higher boiling fraction of camphor blue oil. More highly hydroxylated sesquiterpenoids possessing the eremophilane carbon skeleton are of interest (Fraga, 1998 and previous reports) because of their biological activity as phytoalexins (Katsui, Yagihashi & Murai, 1982) and as toxic fungal metabolites (Moreau et al., 1980). Although there is a report (Paknikar & Dhavlikar, 1975) of the bacterial conversion of valencene to dihydro-α-agarofuran, there have not been any reports (Lamare & Furstoss, 1990) on the microbiological hydroxylation of valerianol. We have therefore examined the biotransformation of valerianol and that of some derivatives by the fungus, Mucor plumbeus.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: James Hanson
Date Deposited: 06 Feb 2012 20:57
Last Modified: 30 Jul 2013 11:09
URI: http://sro.sussex.ac.uk/id/eprint/28815
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