Susceptibility of a Field-Derived, Bacillus thuringiensis-Resistant Strain of Diamondback Moth to In Vitro-Activated Cry1Ac Toxin

Sayyed, Ali H, Gatsi, Roxani, Kouskoura, Thaleia, Wright, Denis J and Crickmore, Neil (2001) Susceptibility of a Field-Derived, Bacillus thuringiensis-Resistant Strain of Diamondback Moth to In Vitro-Activated Cry1Ac Toxin. Applied and Environmental Microbiology, 67 (9). pp. 4372-4373. ISSN 0099-2240

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Abstract

Resistant and susceptible populations of the diamondback moth (Plutella xylostella) were tested with crystalline, solubilized, and partially and fully activated forms of the Bacillus thuringiensis Cry1Ac -endotoxin. Fully activated toxin greatly reduced the resistance ratio (ratio of the 50% lethal concentration for the resistant population to that for the susceptible population) of the resistant population, suggesting that a defect in toxin activation is a major resistance mechanism.

Item Type: Article
Additional Information: NC directed this work, all material was prepared by Gatsi and Kouskoura at Sussex with insect bioassays being performed by collaborators in London. The work describes how the enzymatic modification of a toxin can partially overcome an insect's resistance to that toxin
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Neil Crickmore
Date Deposited: 06 Feb 2012 20:54
Last Modified: 26 Mar 2012 08:22
URI: http://sro.sussex.ac.uk/id/eprint/28659
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