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Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness.

journal contribution
posted on 2023-06-08, 08:05 authored by David C Hughes, P Kevin Legan, Karen P Steel, Guy Richardson
a-Tectorin is one of the major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped the gene encoding a-tectorin to mouse chromosome 9 and human chromosome 11 in a known region of conserved synteny. Human YAC clones containing a-tectorin have been identified, demonstrating physical linkage to the anonymous marker D11S925. This places a-tectorin within the genetic interval that contains both the human nonsyndromic autosomal dominant deafness DFNA12 and the proximal limit of a subset of deletions within Jacobsen syndrome. Thus both DFNA12 and the hearing loss in some cases of Jacobsen syndrome may be due to haploinsufficiency for TECTA.

History

Publication status

  • Published

Journal

Genomics

ISSN

08887543

Publisher

Genomics

Issue

1

Volume

48

Page range

46-51

ISBN

0888-7543

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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