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Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness.
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posted on 2023-06-08, 08:05 authored by David C Hughes, P Kevin Legan, Karen P Steel, Guy Richardsona-Tectorin is one of the major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped the gene encoding a-tectorin to mouse chromosome 9 and human chromosome 11 in a known region of conserved synteny. Human YAC clones containing a-tectorin have been identified, demonstrating physical linkage to the anonymous marker D11S925. This places a-tectorin within the genetic interval that contains both the human nonsyndromic autosomal dominant deafness DFNA12 and the proximal limit of a subset of deletions within Jacobsen syndrome. Thus both DFNA12 and the hearing loss in some cases of Jacobsen syndrome may be due to haploinsufficiency for TECTA.
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Publication status
- Published
Journal
GenomicsISSN
08887543Publisher
GenomicsPublisher URL
External DOI
Issue
1Volume
48Page range
46-51ISBN
0888-7543Department affiliated with
- Neuroscience Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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