Unexpected structure of Epstein–Barr virus lytic cycle activator Zta

Sinclair, Alison J. (2006) Unexpected structure of Epstein–Barr virus lytic cycle activator Zta. Trends in Microbiology, 14 (7). pp. 289-291. ISSN 0966-842X

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Abstract

The key viral gene responsible for initiating the replicative cycle of EpsteinBarr virus (EBV), termed BZLF1, encodes the multifunctional protein Zta (ZEBRA or Z). It interacts with DNA as both a transcription and a replication factor, modulates both intracellular signal transduction and the DNA-damage response and manipulates cell cycle progression. Muller and colleagues have resolved the structure of Zta bound to DNA, which confirms some structural predictions but reveals an unexpected twist and a complex dimerization interface. Because EBV is associated with human disease, Zta presents a prime target for drug design.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Alison Sinclair
Date Deposited: 06 Feb 2012 20:49
Last Modified: 30 Mar 2012 14:34
URI: http://sro.sussex.ac.uk/id/eprint/28329
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