From genetics to pathology: tau and a-synuclein assemblies in neurodegenerative diseases

Goedert, Michel, Spillantini, Maria Grazia, Serpell, Louise C, Berriman, John, Smith, Michael J, Jakes, Ross and Crowther, R Anthony (2001) From genetics to pathology: tau and a-synuclein assemblies in neurodegenerative diseases. Philosophical Transactions B: Biological Sciences, 356 (1406). pp. 213-227. ISSN 1471-2970

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Abstract

The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule¿associated protein tau or the protein a¿synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutations in the a¿synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and a¿synuclein can cause neurodegeneration.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Louise Serpell
Date Deposited: 06 Feb 2012 20:46
Last Modified: 17 May 2012 15:31
URI: http://sro.sussex.ac.uk/id/eprint/28057
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