Efficient Synthesis of Highly Active Phospha-Isosteres of the Influenza Neuraminidase Inhibitor Oseltamivir

Carbain, Benoit, Collins, Patrick J, Callum, Lori, Martin, Stephen R, Hay, Alan J, McCauley, John and Streicher, Hansjorg (2009) Efficient Synthesis of Highly Active Phospha-Isosteres of the Influenza Neuraminidase Inhibitor Oseltamivir. ChemMedChem, 4 (3). pp. 335-337. ISSN 1860-7179

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Abstract

With a HunsdieckerBarton iododecarboxylation strategy, we converted the carboxylate group of the oseltamivir precursor into exemplary phosphonate monoesters. In all cases, Ki values towards influenza virus sialidase remained in the sub-nanomolar range. We have thus made valuable structural space available for the design of novel oseltamivir-based tools for influenza virus research.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Benoit Carbain
Date Deposited: 06 Feb 2012 20:46
Last Modified: 30 Nov 2012 17:08
URI: http://sro.sussex.ac.uk/id/eprint/28028
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