Investigation of multimerisation region of the KSHV (HHV8) encoded protein K-bZIP: the proposed leucine zipper region encodes a multimerisation domain with an unusual structure

Al Mehairi, Salama, Cerasoli, Eleonora and Sinclair, Alison J. (2005) Investigation of multimerisation region of the KSHV (HHV8) encoded protein K-bZIP: the proposed leucine zipper region encodes a multimerisation domain with an unusual structure. Journal of Virology, 79 (12). pp. 7905-7910. ISSN 0022-538X

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Abstract

The K8 gene of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr virus. The protein products of K8 and BZLF1, K-bZIP (RAP, K8) and Zta (BZLF1, ZEBRA, Z) have both been proposed to be members of the bZIP family of transcription factors, forming multimers via a coiled-coil motif termed a leucine zipper. Substantial evidence supporting this model for Zta is published. Here, we demonstrate that the proposed leucine zipper region of K-bZIP (amino acids 182 to 218) is required for multimer formation but that it does not fold as a coiled coil.

Item Type: Article
Additional Information: This research was undertaken in Dr Sinclair's laboratory. This is the first biophysical investigation of the K-bZIP protein encoded by KSHV. The conclusions presented alter the working model of the physical structure of K-bZIP.
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Alison Sinclair
Date Deposited: 06 Feb 2012 20:45
Last Modified: 30 Mar 2012 14:44
URI: http://sro.sussex.ac.uk/id/eprint/27982
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