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Applications of DNP-NMR for the measurement of heteronuclear T1 relaxation times
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posted on 2023-06-08, 07:42 authored by Iain Day, John C Mitchell, Martin J Snowden, Adrian L DavisMeasurement of heteronuclear spinlattice relaxation times is hampered by both low natural abundance and low detection sensitivity. Combined with typically long relaxation times, this results in extended acquisition times which often renders the experiment impractical. Recently a variant of dynamic nuclear polarisation has been demonstrated in which enhanced nuclear spin polarisation, generated in the cryo-solid state, is transferred to the liquid state for detection. Combining this approach with small flip angle pulse trains, similar to the FLASH-T1 imaging sequence, allows the rapid determination of spinlattice relaxation times. In this paper we explore this method and its application to the measurement of T1 for both carbon-13 and nitrogen-15 at natural abundance. The effects of RF inhomogeneity and the influence of proton decoupling in the context of this experiment are also investigated.
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Publication status
- Published
Journal
Journal of Magnetic ResonanceISSN
1090-7807Publisher
ElsevierExternal DOI
Issue
2Volume
187Page range
216-224Department affiliated with
- Chemistry Publications
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- No
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- Yes
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2012-02-06Usage metrics
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