Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity

Cannell, Emma J, Farrell, Paul J and Sinclair, Alison J (1998) Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity. FEBS Letters, 439 (3). pp. 297-301. ISSN 0014-5793

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Abstract

The exposure of Epstein-Barr virus immortalised B cells (LCLs) to the genotoxic effects of gamma irradiation causes a decreased proliferation of the cells. The early events in this process have been investigated here. The induction of p53 expression correlates with a cell cycle arrest in the G1 and G2/M phases of the cell cycle within 24 h of exposure, The molecular mechanism governing the decreased proliferation appears to involve the induction of the cyclin dependent kinase (cdk) inhibitor p21(CIP1) and its functional association with cdk2, (C) 1998 Federation of European Biochemical Societies.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Alison Sinclair
Date Deposited: 06 Feb 2012 20:43
Last Modified: 30 Mar 2012 15:36
URI: http://sro.sussex.ac.uk/id/eprint/27664
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