Control of Central Synaptic Specificity in Insect Sensory Neurons

Blagburn, Jonathan M and Bacon, Jonathan P (2004) Control of Central Synaptic Specificity in Insect Sensory Neurons. Annual Review of Neuroscience, 27. pp. 29-51. ISSN 0147-006X

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Abstract

Synaptic specificity is the culmination of several processes, beginning with the establishment of neuronal subtype identity, followed by navigation of the axon to the correct subdivision of neuropil, and finally, the cell-cell recognition of appropriate synaptic partners. In this review we summarize the work on sensory neurons in crickets, cockroaches, moths, and fruit flies that establishes some of the principles and molecular mechanisms involved in the control of synaptic specificity. The identity of a sensory neuron is controlled by combinatorial expression of transcription factors, the products of patterning and proneural genes. In the nervous system, sensory axon projections are anatomically segregated according to modality, stimulus quality, and cell-body position. A variety of cell-surface and intracellular signaling molecules are used to achieve this. Synaptic target recognition is also controlled by transcription factors such as Engrailed and may be, in part, mediated by cadherin-like molecules.

Item Type: Article
Additional Information: Jonathan Blagburn and I co-wrote this review and refer very heavily to our own work in this area.
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Jonathan Bacon
Date Deposited: 06 Feb 2012 20:37
Last Modified: 22 Mar 2012 10:45
URI: http://sro.sussex.ac.uk/id/eprint/27085
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