The evolution of isochores

Eyre-Walker, Adam and Hurst, Laurence D (2001) The evolution of isochores. Nature Reviews Genetics. pp. 549-555. ISSN 1471-0056

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Abstract

One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 20:37
Last Modified: 22 Mar 2012 10:42
URI: http://sro.sussex.ac.uk/id/eprint/27047
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