Replication of Damaged DNA

Lehmann, Alan R. (2003) Replication of Damaged DNA. Cell Cycle, 2 (4). pp. 300-302. ISSN 1538-4101

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Abstract

DNA damage is generated continually inside cells. In order to be able to replicate past damaged bases (translesion synthesis), the cell employs a series of specialised DNA polymerases, which singly or in combination, are able to bypass many different types of damage. The polymerases have similar structural domains to classical polymerases, but they have a more open structure to allow altered bases to fit into their active sites. Although not required for replication of undamaged DNA, some at least of these polymerases are located in replication factories. Emerging evidence suggests that the polymerase switch from replicative to translesion polymerases might be mediated by post-translational modifications

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
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Depositing User: Alan Lehmann
Date Deposited: 06 Feb 2012 20:37
Last Modified: 24 Jul 2012 10:30
URI: http://sro.sussex.ac.uk/id/eprint/27012
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