Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

Kros, C J, Marcotti, W, van Netten, S M, Self, T J, Libby, R T, Brown, S D M, Richardson, G P and Steel, K P (2002) Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations. Nature Neuroscience, 5 (1). pp. 41-47. ISSN 1097-6256

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Abstract

Mutations in Myo7a cause hereditary deafness in mice and humans. We describe the effects of two mutations, Myo7a6J and Myo7a4626SB, on mechano-electrical transduction in cochlear hair cells. Both mutations result in two major functional abnormalities that would interfere with sound transduction. The hair bundles need to be displaced beyond their physiological operating range for mechanotransducer channels to open. Transducer currents also adapt more strongly than normal to excitatory stimuli. We conclude that myosin VIIA participates in anchoring and holding membrane-bound elements to the actin core of the stereocilium. Myosin VIIA is therefore required for the normal gating of transducer channels.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Corne Kros
Date Deposited: 06 Feb 2012 20:32
Last Modified: 26 Mar 2012 11:09
URI: http://sro.sussex.ac.uk/id/eprint/26483
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