Maesaquinone: A novel inhibitor of plant mitochondrial respiratory enzymes that react with ubiquinone

Affourtit, Charles, Whitehouse, David G and Moore, Anthony L (2000) Maesaquinone: A novel inhibitor of plant mitochondrial respiratory enzymes that react with ubiquinone. IUBMB Life, 49 (6). pp. 533-537. ISSN 1521-6543

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Abstract

The effect of maesaquinone, 2-(14-nonadecenyl)-3,6-dihydroxy-5-methyl-1,4-benzoquinone, on plant mitochondrial respiration has been investigated, In mitochondria isolated from thermogenic Arum maculatum spadices, this compound inhibits both cytochrome and alternative pathway activities, Kinetic analyses reveal that this inhibition is the result of potent effects of maesaquinone on the alternative oxidase (ID50 < 0.3 mu M) and complex III (ID50 < 5 mu M). Succinate dehydrogenase and external NADH dehydrogenase are also inhibited, albeit to a lesser extent (similar to 30% at 1 mu M). These data suggest that maesaquinone specifically affects the interaction of the respective enzymes with ubiquinone

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: David Whitehouse
Date Deposited: 06 Feb 2012 20:21
Last Modified: 25 Apr 2012 14:11
URI: http://sro.sussex.ac.uk/id/eprint/25546
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