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Maesaquinone: A novel inhibitor of plant mitochondrial respiratory enzymes that react with ubiquinone

journal contribution
posted on 2023-06-08, 06:01 authored by Charles Affourtit, David G Whitehouse, Anthony Moore
The effect of maesaquinone, 2-(14-nonadecenyl)-3,6-dihydroxy-5-methyl-1,4-benzoquinone, on plant mitochondrial respiration has been investigated, In mitochondria isolated from thermogenic Arum maculatum spadices, this compound inhibits both cytochrome and alternative pathway activities, Kinetic analyses reveal that this inhibition is the result of potent effects of maesaquinone on the alternative oxidase (ID50 < 0.3 mu M) and complex III (ID50 < 5 mu M). Succinate dehydrogenase and external NADH dehydrogenase are also inhibited, albeit to a lesser extent (similar to 30% at 1 mu M). These data suggest that maesaquinone specifically affects the interaction of the respective enzymes with ubiquinone

History

Publication status

  • Published

Journal

IUBMB Life

ISSN

1521-6543

Publisher

Wiley-Blackwell

Issue

6

Volume

49

Page range

533-537

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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