Studies towards the synthesis of rapamycin: Regiocontrol in the addition of carbanions to enantiomerically pure epoxides and the formation of a highly substituted tetrahydrofuran

Oh, Kyung Soo, Cheshire, David and Parsons, Philip J (2005) Studies towards the synthesis of rapamycin: Regiocontrol in the addition of carbanions to enantiomerically pure epoxides and the formation of a highly substituted tetrahydrofuran. Synlett, - (10). pp. 1630-1632. ISSN 09365214

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Abstract

Reaction of trimethylaluminium, dimethyllithium cuprate and lithium tetramethylaluminate with the homochiral epoxide 8 has been studied. Intermolecular epoxide ring-opening was observed with dimethyllithium cuprate and lithium tetramethylaluminate, but acetal ring-opening followed by intramolecular epoxide ring-opening was observed with trimethylaluminium.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Philip Parsons
Date Deposited: 06 Feb 2012 20:19
Last Modified: 27 Mar 2012 10:59
URI: http://sro.sussex.ac.uk/id/eprint/25396
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