McKay, L.C., Critchley, H.D., Murphy, K., Frackowiak, R.S.J. and Corfield, D.R. (2010) Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans. Neuroimage, 49 (3). pp. 2526-2535. ISSN 10538119Full text not available from this repository.
We investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2* weighted echo planar imaging. Brain volumes (52 transverse slices, cortex to high spinal cord) were acquired every 3.9 s. The 30 min paradigm consisted of six, 5-min cycles, each cycle comprising 45 s of hypoxic-isocapnia, 45 s of isooxic-hypercapnia and 45 s of hypoxic-hypercapnia, with 55 s of non-stimulatory hyperoxic-isocapnia (control) separating each stimulus period. Ventilation was significantly (p < 0.001) increased during hypoxic-isocapnia, isooxic-hypercapnia and hypoxic-hypercapnia (17.0, 13.8, 24.9 L/min respectively) vs. control (8.4 L/min) and was associated with significant (p < 0.05, corrected for multiple comparisons) signal increases within a bilateral network that included the basal ganglia, thalamus, red nucleus, cerebellum, parietal cortex, cingulate and superior mid pons. The neuroanatomical structures identified provide evidence for the spontaneous control of breathing to be mediated by higher brain centres, as well as respiratory nuclei in the brainstem. © 2009 Elsevier Inc. All rights reserved.
|Additional Information:||PubMed ID: 19913627|
|Schools and Departments:||Brighton and Sussex Medical School > Clinical Medicine|
|Subjects:||Q Science > Q Science (General)
R Medicine > R Medicine (General)
Q Science > QZ Psychology
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
|Depositing User:||Hazelle Woodhurst|
|Date Deposited:||28 Oct 2010|
|Last Modified:||30 Nov 2012 16:54|