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Mechanisms of Resistance to Bacillus thuringiensis in the Diamondback Moth
journal contribution
posted on 2023-06-08, 05:45 authored by Mark J Bruce, Roxani Gatsi, Neil CrickmoreNeil Crickmore, Ali H SayyedPlutella xylostella, the diamondback moth, has become a model organism for the study of resistance to Bacillus thuringiensis based insecticides, since it is the only insect that has readily acquired resistance to this agent in the field. A number of different mechanisms have been proposed that result in this resistance phenotype, including the loss of a midgut binding site and the reduced activation of protoxin to toxin. The latter mechanism has been proposed on the basis of resistant insects being more susceptible to toxin than protoxin. We investigated whether a reduction in proteolytic activity, and consequently toxin activity, could be the basis of the resistant phenotype. Our results suggest that there was no qualitative difference in the protease activity between gut extract from susceptible and resistant populations. In this paper we review the different resistant mechanism proposed for this insect and critically analyse the hypothesis that the preferential activity of toxin compared to protoxin is due to a defect in activation.
History
Publication status
- Published
Journal
Biopesticides InternationalISSN
0973-483XIssue
1Volume
3Page range
1-12Pages
12.0Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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