The decline of isochores in mammals: an assessment of the GC content variation along the mammalian phylogeny.

Belle, Elise M S, Duret, Laurent, Galtier, Nicolas and Eyre-Walker, Adam (2004) The decline of isochores in mammals: an assessment of the GC content variation along the mammalian phylogeny. Journal of Molecular Evolution, 58 (6). pp. 653-660. ISSN 0022-2844

Full text not available from this repository.

Abstract

Whether isochores, the large-scale variation of the GC content in mammalian genomes, are being maintained has recently been questioned. It has been suggested that GC-rich isochores originated in the ancestral amniote genome but that whatever force gave rise to them is no longer effective and that isochores are now disappearing from mammalian genomes. Here we investigated the evolution of the GC content of 41 coding genes in 6 to 66 species of mammals by estimating the ancestral GC content using a method which allows for different rates of substitution between sites. We found a highly significant decrease in the GC content during early mammalian evolution, as well as a weaker but still significant decrease in the GC content of GC-rich genes later in at least three groups of mammals: primates, rodents, and carnivores. These results are of interest because they confirm the recently suggested disappearance of GC-rich isochores in some mammalian genomes, and more importantly, they suggest that this disappearance started very early in mammalian evolution.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 20:14
Last Modified: 21 Mar 2012 14:13
URI: http://sro.sussex.ac.uk/id/eprint/24847
📧 Request an update