Antagonists of the human adenosine A(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d] pyrimidine-4-methanone derivatives

Ward, Simon (2008) Antagonists of the human adenosine A(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d] pyrimidine-4-methanone derivatives. Bioorganic & Medicinal Chemistry Letters, 18 (9). pp. 2916-2919. ISSN 0960894X

Full text not available from this repository.

Abstract

The (-)-(11R,2'S)-enantiomer of the antimalarial drug mefloquine has been found to be a reasonably potent and moderately selective adenosine A(2A) receptor antagonist. Further investigation of this compound has led to the discovery of a series of keto-aryl thieno[3,2-d]pyrimidine derivatives, which are potent and selective antagonists of the adenosine A(2A) receptor. These derivatives show selectivity against the A(1) receptor. Furthermore, some of these compounds have been shown to have in vivo activity in a commonly used model, suggesting the potential for the treatment of Parkinson's disease

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Simon Ward
Date Deposited: 06 Feb 2012 20:11
Last Modified: 31 May 2012 16:19
URI: http://sro.sussex.ac.uk/id/eprint/24549
📧 Request an update