5-HT2C receptor activation inhibits appetitive and consummatory components of feeding and increases brain c-fos immunoreactivity in mice

Somerville, Elizabeth M, Horwood, Julia M, Lee, Michelle D, Kennett, Guy A and Clifton, Peter G (2007) 5-HT2C receptor activation inhibits appetitive and consummatory components of feeding and increases brain c-fos immunoreactivity in mice. European Journal of Neuroscience, 25 (10). pp. 3115-3124. ISSN 1460-9568

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Abstract

5-Hydroxytryptamine (5-HT)2C and 5-HT1B receptors are implicated in the inhibitory modulation of feeding behaviour. However, their respective, and possibly different, roles have not been clearly identified because of a lack of selective 5-HT2C receptor agonists. Here, using the putative, selective 5-HT2C receptor agonist VER23779, we show that its effects on feeding are fully reversed by pretreatment with a selective 5-HT2C receptor antagonist, but unaffected by pretreatment with either a 5-HT1B or a 5-HT2A receptor antagonist. In mice eating a palatable mash, feeding ends earlier, inactivity is increased but the behavioural satiety sequence is preserved. In a second-order schedule of reinforcement with an initial, non-food-reinforced appetitive phase, VER23779 produces a much greater relative reduction in appetitive responding than the 5-HT1B receptor agonist CP-94,253. Increased c-fos immunoreactivity patterns following VER23779 also differ from those described for CP-94,253, in particular showing strong activation of the basolateral amygdala. The different behavioural consequences of 5-HT2C and 5-HT1B receptor activation may relate to the patterns of c-fos immunoreactivity. In particular, the basolateral amygdala may have a role in maintaining response in the appetitive phase of the second-order schedule and also be susceptible to serotonergic modulation through activation of 5-HT2C receptors.

Item Type: Article
Additional Information: E.M.Somerville supervised the neuroanatomical work and analysed c-fos results. E.M.Somerville co-authored the paper in collaboration with P.G.Clifton. This study uses a selective 5HT-2C agonist to demonstrate the contrast between two serotoninergic receptors in feeding behaviour and the correlation of this with a neuroanatomical measure of CNS activation.
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Liz Somerville
Date Deposited: 06 Feb 2012 20:11
Last Modified: 26 Mar 2012 08:28
URI: http://sro.sussex.ac.uk/id/eprint/24528
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