Exploring the molecular nature of alternative oxidase regulation and catalysis.

Affourtit, Charles, Albury, Mary S, Crichton, Paul G and Moore, Anthony L (2002) Exploring the molecular nature of alternative oxidase regulation and catalysis. FEBS Letters, 510 (3). pp. 121-126. ISSN 0014-5793

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Abstract

Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water. In this paper we review theoretical and experimental studies that have contributed to our current structural and mechanistic understanding of the oxidase and to the clarification of the molecular nature of post-translational regulatory phenomena. Furthermore, we suggest a catalytic cycle for AOX that involves at least one transient protein-derived radical. The model is based on the reviewed information and on recent insights into the mechanisms of cytochrome c oxidase and the hydroxylase component of methane monooxygenase.

Item Type: Article
Additional Information: Co-authors all post docs in my lab where the work was carried out.
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Mary Albury
Date Deposited: 06 Feb 2012 20:10
Last Modified: 22 Mar 2012 11:17
URI: http://sro.sussex.ac.uk/id/eprint/24508
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