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Identification and characterisation of Schizosaccharomyces pombe cyclophilin 3 and its human homologue cyclophilin 20
journal contribution
posted on 2023-06-08, 00:52 authored by Trevor J Pemberton, Stuart L Rulten, John E KayWe have identified nine cyclophilins encoded in the genome of the fission yeast Schizosaccharomyces pombe (Sp). Cyclophilin 3 is an orthologue of hUSA-CyP, which is associated with Prp4/Prp3 in the [U4/U6·U5] snRNP complex and Prp18, both of which are components of the pre-mRNA splicing machinery. PPIase assays have shown SpCyp3 and hUSA-CyP to have comparable activity and substrate specificity, but SpCyp3 has a reduced sensitivity to CsA correlating with a difference in the catalytic site. Prp3, Prp4 and Prp18 proteins exist in S. pombe and nuclear localisation of SpCyp3 has been shown, indicating conservation of function between hUSA-CyP and SpCyp3.
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Publication status
- Published
Journal
Journal of Chromatography BISSN
1570-0232Publisher
ElsevierExternal DOI
Issue
1-2Volume
786Page range
81-91Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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