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Life can be stressful without ATR

journal contribution
posted on 2023-06-07, 15:10 authored by Mark O'DriscollMark O'Driscoll
A new study reports the first mouse model for ATR-mutated Seckel syndrome. The mice show phenotypes recapitulating the human disorder and provide insights into how reduced ATR function affects normal embryonic development by increasing replicative stress, ultimately resulting in an accelerated aging phenotype postnatally.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Genetics

ISSN

1061-4036

Publisher

Nature Publishing Group

Issue

8

Volume

41

Page range

866-868

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

GDSC291

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2009-09-21

First Compliant Deposit (FCD) Date

2018-03-19

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