UVB and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UVB

Kerzendorfer, Claudia and O'Driscoll, Mark (2009) UVB and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UVB. Journal of Investigative Dermatology, 129 (7). pp. 1611-1613. ISSN 0022-202X

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Abstract

The incidence of sunlight-induced skin cancer is increasing. Mouse studies indicate that caffeine, administered orally or topically, promotes apoptosis of UVB-irradiated keratinocytes. In this issue, Heffernan and colleagues identify the pathway targeted by caffeine and suggest that inhibition of this DNA damage response may offer a viable therapeutic option for nonmelanoma skin cancer. This potentially represents an important protective or therapeutic option from the most unlikely of sources: your daily coffee.

Item Type: Article
Additional Information: GDSC290
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Gee Wheatley
Date Deposited: 21 Sep 2009
Last Modified: 19 Mar 2018 16:00
URI: http://sro.sussex.ac.uk/id/eprint/2239
Google Scholar:7 Citations

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