Synthesis of sulfur-containing analogues of alpha GalNAc (Tn-antigen) and beta Gal1,3 alpha GalNAc (T-antigen)

Wenzl, Irmgard, Neuwirth, Norbert, Hedenetz, Alexander G, Fiedler, Christian, Streicher, Hansjorg, Unger, Frank M and Schmid, W (2002) Synthesis of sulfur-containing analogues of alpha GalNAc (Tn-antigen) and beta Gal1,3 alpha GalNAc (T-antigen). Chemical Monthly / Monatshefte für Chemie, 133 (4). pp. 531-540. ISSN 0026-9247

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Abstract

A method for the preparation of thio-analogues of the T- and Tn-antigen was developed. Thus, starting from a known N-acetamido-glucoside derivative, the epidithio analogue of the Tn-antigen was accessible in a four-step reaction sequence. The corresponding epidithio analogue and the thioanhydro derivative of the T-antigen were synthesized starting from a disaccharide derivative. For the preparation of the epidithio analogue the sulfur atoms were introduced via thiocyanates in a stepwise fashion, using mesylate as the leaving group at C-6 and triflate as the leaving group at C-4 in the reducing carbohydrate moiety. The synthesis of the thioanhydro analogue was achieved by introducing a thiocyanate group at C-6 into the glucose moiety, followed by subsequent displacement of a mesylate group at C-4 under inversion of configuration utilizing sodium methoxide.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Hans Streicher
Date Deposited: 06 Feb 2012 19:46
Last Modified: 08 May 2012 15:22
URI: http://sro.sussex.ac.uk/id/eprint/22120
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