Simultaneous determination of endocrine disrupting phenolic compounds and steriods in water by solid-phase extraction-gas chromatography-mass spectrometry

Liu, R, Zhou, J L and Wilding, A (2004) Simultaneous determination of endocrine disrupting phenolic compounds and steriods in water by solid-phase extraction-gas chromatography-mass spectrometry. Journal of Chromatography A, 1022 (1-2). pp. 179-189. ISSN 0021-9673

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Abstract

A solid phase extraction (SPE)-GC/MS analytical method for the simultaneous separation and determination of endocrine disrupting chemicals (EDCs) from water samples is described in detail. Important and contrasting EDCs including estrone, 17N2-estradiol, 17a-ethynylestradiol, 16a-hydroxyestrone, 4-nonylphenol, bisphenol A and 4-tert-octylphenol were selected as the target compounds. The SPE technique, followed by the derivatisation with BSTFA was used for the extraction recoveries of target compounds from water samples. A number of parameters that may affect the recovery of EDCs such as the type of SPE cartridges, eluents, as well as water properties including pH value, concentration of salts and humic substances were investigated. It is shown that the Oasis cartridges produced the best recoveries of target EDCs while ethyl acetate was efficient in eluting EDCs from SPE cartridges. The recovery of some EDCs was enhanced by the addition of salt, but reduced by the increase in pH value and humic acid concentration. The optimised method was further verified by performing spiking experiments in natural river water and seawater matrices, with good recovery and reproducibility for all the selected compounds. The established method was successfully applied to environmental water samples from East and West Sussex, UK, for the determination of the target EDCs.

Item Type: Article
Additional Information: JZ planned and led the work and was the corresponding author. This paper has been cited for over 50 times since publication. It is a comprehensive method development for the simultaneous measurement of EDCs under a range of environmental conditions.
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Depositing User: John Zhou
Date Deposited: 06 Feb 2012 19:44
Last Modified: 21 Mar 2012 08:58
URI: http://sro.sussex.ac.uk/id/eprint/22001
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