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A recurring theme in protein engineering: the design, stability and folding of repeat proteins

journal contribution
posted on 2023-06-07, 23:51 authored by Ewan Main
Repeat proteins are ubiquitous and are involved in a myriad of essential processes. They are typically non-globular structures that act as diverse scaffolds for the mediation of protein-protein interactions. These excitingly different structures, which arise from tandem arrays of a repeated structural motif, have generated significant interest with respect to protein engineering and design. Recent advances have been made in the design and characterisation of repeat proteins. The highlights include re-engineering of binding specificity, quantitative models of repeat protein stability and kinetic studies of repeat protein folding.

History

Publication status

  • Published

Journal

Current Opinion in Structural Biology

ISSN

0959440X

Publisher

Elsevier

Issue

4

Volume

15

Page range

464-71

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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