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A recurring theme in protein engineering: the design, stability and folding of repeat proteins
journal contribution
posted on 2023-06-07, 23:51 authored by Ewan MainRepeat proteins are ubiquitous and are involved in a myriad of essential processes. They are typically non-globular structures that act as diverse scaffolds for the mediation of protein-protein interactions. These excitingly different structures, which arise from tandem arrays of a repeated structural motif, have generated significant interest with respect to protein engineering and design. Recent advances have been made in the design and characterisation of repeat proteins. The highlights include re-engineering of binding specificity, quantitative models of repeat protein stability and kinetic studies of repeat protein folding.
History
Publication status
- Published
Journal
Current Opinion in Structural BiologyISSN
0959440XPublisher
ElsevierPublisher URL
Issue
4Volume
15Page range
464-71Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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