Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst

Cawley, M J, Cloke, F Geoffrey N, Fitzmaurice, R J, Pearson, S E, Scott, J S and Caddick, S (2008) Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst. Organic and Biomolecular Chemistry, 6 (15). pp. 2820-2825. ISSN 1477-0520

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Abstract

Continuing efforts to establish a more general "user-friendly" protocol for the palladium-catalysed arylation of amines (Buchwald-Hartwig reaction) are described herein. Significant advances have been made through the use of the versatile (SIPr)Pd(methallyl)Cl complex in conjunction with the reliable base lithium hexamethyldisilazide (LHMDS).

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Geoff Cloke
Date Deposited: 06 Feb 2012 19:43
Last Modified: 30 Nov 2012 17:04
URI: http://sro.sussex.ac.uk/id/eprint/21946
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