Stereochemistry of the reaction of the inhibitor β-chloroalanine with mercaptoethanol, a β-substitution reaction catalysed by an aminotransferase

Adams, Benjamin, Beresford, Kenneth J M, Whyte, Sheena M and Young, Douglas W (2000) Stereochemistry of the reaction of the inhibitor β-chloroalanine with mercaptoethanol, a β-substitution reaction catalysed by an aminotransferase. Chemical Communications, 7. 619 - 620.

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Abstract

L-Aspartate aminotransferase, a member of the α-family of PLP mediated enzymes, which normally catalyses transamination, has been used to catalyse the β-substitution reaction of stereospecifically labelled samples of the enzyme inhibitor β-chloro-L-alanine with 2-mercaptoethanol; the stereochemistry of the products was assigned by independent synthesis, showing that the abnormal substitution reaction proceeds with overall retention of stereochemistry, the usual stereochemical consequence of reactions catalysed by enzymes of the β-family of PLP mediated enzymes which have low homology with enzymes of the α-family

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 19:43
Last Modified: 29 Mar 2012 06:16
URI: http://sro.sussex.ac.uk/id/eprint/21857
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