How Bacillus thuringiensis has evolved specific toxins to colonize the insect world

de Maagd, Ruud A, Bravo, Alejandra and Crickmore, Neil (2001) How Bacillus thuringiensis has evolved specific toxins to colonize the insect world. Trends in Genetics, 17 (4). pp. 193-199. ISSN 0168-9525

Full text not available from this repository.

Abstract

Bacillus thuringiensis is a bacterium of great agronomic and scientific interest. Together the subspecies of this bacterium colonize and kill a large variety of host insects and even nematodes, but each strain does so with a high degree of specificity. This is mainly determined by the arsenal of crystal proteins that the bacterium produces during sporulation. Here we describe the properties of these toxin proteins and the current knowledge of the basis for their specificity. Assessment of phylogenetic relationships of the three domains of the active toxin and experimental results indicate how sequence divergence in combination with domain swapping by homologous recombination might have caused this extensive range of specificities.

Item Type: Article
Additional Information: Co-author
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Neil Crickmore
Date Deposited: 06 Feb 2012 19:42
Last Modified: 21 Mar 2012 12:53
URI: http://sro.sussex.ac.uk/id/eprint/21852
📧 Request an update