Novel roles for prestin in frequency tuning and neural excitation in the mouse cochlea

Mellado Lagarde, , Drexl, , Lukashkin, , Zuo, and Russell, (2009) Novel roles for prestin in frequency tuning and neural excitation in the mouse cochlea. In: 10th International Workshop on the Mechanics of Hearing Keele Univ, Staffordshire, ENGLAND, JUL 27-31, 2008, Keele Univ, Staffordshire, ENGLAND.

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Abstract

The motor protein prestin in the outer hair cells is a prime candidate for the molecular amplifier that ensures the sensitivity, frequency tuning and dynamic range of the mammalian cochlea. Absence of prestin results in a 40-60 dB reduction in cochlear neural sensitivity. Here we show that sound-evoked basilar membrane (BM) vibrations in the basal cochleae of prestin(-/-) mice are as sensitive as those of their prestin(+/+) siblings. BM vibrations in prestin(-/-) mice are, however, broadly tuned to a frequency similar to a half octave below the characteristic frequency (CF) of similar BM locations in prestin(+/+) mice. The peak sensitivity of prestin(+/+) BM tuning curves matches the neural thresholds, while prestin(-/-) BM tuning curves at the best frequency are > 50 dB more sensitive than the neural responses. We conclude that prestin influences properties of the cochlear partition that are crucial for BM frequency tuning and for converting its vibrations into neural excitation.

Item Type: Conference or Workshop Item (Paper)
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Depositing User: Andrei Lukashkin
Date Deposited: 06 Feb 2012 19:42
Last Modified: 22 Mar 2012 15:25
URI: http://sro.sussex.ac.uk/id/eprint/21804
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