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Problems with parsimony in sequences of biased base composition
Parsimony is commonly used to infer the direction of substitution and mutation. However, it is known that parsimony is biased when the base composition of the DNA sequence is skewed. Here I quantify this effect for several simple cases. The analysis demonstrates that parsimony can be misleading even when levels of sequence divergence are as low as 10%; parsimony incorrectly infers an excess of common to rare changes. Caution must therefore be excercised in the use of parsimony.
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Publication status
- Published
Journal
Journal of Molecular EvolutionISSN
0022-2844Publisher
Springer VerlagExternal DOI
Issue
6Volume
47Page range
686-690Pages
5.0Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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