Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?

Lehmann, Alan R, Friedberg, Errol C and Fuchs, Robert P P (2005) Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis? Molecular Cell, 18 (5). pp. 499-505. ISSN 1097-2765

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Abstract

The replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a ubiquitous mechanism for relieving arrested DNA replication. The process requires multiple polymerase switching events during which the high-fidelity DNA polymerase in the replication machinery arrested at the primer terminus is replaced by one or more polymerases that are specialized for TLS. When replicative bypass is fully completed, the primer terminus is once again occupied by high-fidelity polymerases in the replicative machinery. This review addresses recent advances in our understanding of DNA polymerase switching during TLS in bacteria such as E. coli and in lower and higher eukaryotes.

Item Type: Article
Additional Information: From SRO
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Alan Lehmann
Date Deposited: 06 Feb 2012 19:38
Last Modified: 30 Mar 2012 10:49
URI: http://sro.sussex.ac.uk/id/eprint/21605
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