Nucl._Acids_Res.-1992-Eyre-Walker-1497-501.pdf (436.11 kB)
Evidence that both G + C rich and G + C poor isochores are replicated early and late in the cell cycle
Since the G + C content of a gene is correlated to that of the isochore in which it resides, and early replicating isochores are thought to be relatively G + C rich, early replicating genes should also be rich in G + C. This hypothesis is tested on a sample of 44 mammalian genes for which replication time data and sequence information are available. Early replicating genes do not appear to be more G + C rich than late replicating genes, instead there is considerable variation in the G + C content of genes replicated during both halves of S phase. These results show that both G + C rich and poor fractions of the genome are replicated early and late in the cell cycle, and suggest that isochores are not maintained by the replication of DNA sequences in compositionally biased free nucleotide pools.
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- Published
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- Published version
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Nucleic Acids ResearchISSN
0305-1048External DOI
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7Volume
20Page range
1497-1501Pages
5.0Department affiliated with
- Evolution, Behaviour and Environment Publications
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- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06First Open Access (FOA) Date
2016-03-22First Compliant Deposit (FCD) Date
2016-11-17Usage metrics
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