Evidence that both G + C rich and G + C poor isochores are replicated early and late in the cell cycle

Eyre-Walker, Adam (1992) Evidence that both G + C rich and G + C poor isochores are replicated early and late in the cell cycle. Nucleic Acids Research, 20 (7). pp. 1497-1501. ISSN 0305-1048

[img]
Preview
PDF - Published Version
Download (446kB) | Preview

Abstract

Since the G + C content of a gene is correlated to that of the isochore in which it resides, and early replicating isochores are thought to be relatively G + C rich, early replicating genes should also be rich in G + C. This hypothesis is tested on a sample of 44 mammalian genes for which replication time data and sequence information are available. Early replicating genes do not appear to be more G + C rich than late replicating genes, instead there is considerable variation in the G + C content of genes replicated during both halves of S phase. These results show that both G + C rich and poor fractions of the genome are replicated early and late in the cell cycle, and suggest that isochores are not maintained by the replication of DNA sequences in compositionally biased free nucleotide pools.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 19:36
Last Modified: 07 Mar 2017 09:46
URI: http://sro.sussex.ac.uk/id/eprint/21483

View download statistics for this item

📧 Request an update